NIH Single IRB Review Policy

Effective September 25, 2017, the NIH requires that all grant applications for domestic, multi-site, non-exempt human subject research studies include a proposal for the use of a single IRB (“sIRB”) to review the research for all participating domestic sites. The Homewood IRB, the School of Medicine (SOM) IRB, and the Johns Hopkins School of Public Health (JHSPH) IRB are working together to address the new NIH requirement for sIRB. When sIRB services are required by a Sponsor, and a JHU PI wants JHU to serve as the study’s sIRB, the SOM IRB will review all requests for sIRB services, and if approved, will serve as the University’s sIRB for all divisions. JHU has signed on to the SMART IRB Reliance agreement, and investigators are urged to make sure that their collaborators have either signed on to this form of reliance agreement, or are willing to sign on.
  • All Planning Phase and New Applications that involve Hopkins as the reviewing sIRB must submit a “Reliance Request” through an on-line SOM IRB query portal available at: http://www.hopkinsmedicine.org/institutional_review_board/about/reliance_agreement.html . Reviewers will evaluate and act on the request. SOM faculty will use the same portal for applications seeking to rely on an external sIRB.
  • Homewood and JHSPH investigators preparing grant submissions and new applications that propose relying on an external sIRB should contact the Homewood IRB (hirb@jhu.edu ) or JHSPH (jhsph.irboffice@jhu.edu ) for further guidance .
All other reliance requests will be managed by the IRB associated with the PI’s division.
Please contact JHMIRBreliance@jhmi.edu with questions about the SOM IRB sIRB process.